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Fillerina® 12HA Densifying rEPLENISHING

Replenishing Effect: 12 Hyaluronic Acids
Densifying Effect: 3 Collagens and 2 Elastins


Fillerina 12HA Densifying-Replenishing dermo-cosmetic
preparations for at-home use come in 3 different concentrations containing
diversified blends of 12 Hyaluronic Acid molecules, 3 Collagens and 2 Elastins,
to be chosen according to skin and wrinkle conditions.


Initial wrinkles and expression lines.

Initial age wrinkles and uneven microrelief.

Initial depression and depletion of the skin.

Skin with decreasing thickness, density and plasticity.
Initial sagging signs.

Need for more plumping to cheekbones and lips.


Deep wrinkles and expression lines.

Age wrinkles with visible, marked and uneven microrelief.

Conspicuous depression and depletion of the skin.

Skin with poor thickness, density and plasticity.

Visible sagging signs.

Need for more plumping to cheekbones and lips.


Very deep wrinkles and expression lines.

Age wrinkles with very marked and uneven microrelief.

Severe depression and depletion of the skin.

Skin with insufficient thickness, density and plasticity.

Marked sagging signs.

Need for more plumping to cheekbones and lips.


Fillerina 12HA Densifying-Replenishing shall be used every
day for 14 days, in the morning or evening, depending on individual needs and
habits, by applying 2 ml of Densifying[1]Replenishing Gel
(Bottle No. 1) on wrinkles, on the most marked microrelief and on areas that
require particular plumpness (cheekbones, lips). To promote Fillerina action,
it is recommended to apply the product on clean skin, free from sebum and
impurities. The application shall be performed by means of the special
Dispenser/Applicator, which allows to draw up two separate 1 ml amounts of
product (adding up to a total of 2 ml per application) and accurately release
it onto the desired areas. The Densifying[1]Replenishing
Gel should be left to work for 10 minutes in order for the ingredients to
“replenish” the application areas. Using the palm of the hands or fingers, pat
in the remaining product to complete the application. Do not carry out rotating
massages or movements to avoid the possible formation of surface residues. Any
feeling of tension on the skin is due to the action of the product. Then apply
the Nourishing Film (Bottle No. 2) which guarantees a sufficient amount of
moisturizing and nourishing substances, and allows the application to be
completed with maximum comfort for the skin of face and neck. Draw up 1 – 2 ml
of Film, as required, and apply it all over face and neck. To facilitate the action
of the product, it is advisable to drink two glasses of water before the
application of Fillerina Gel.

After the first 14 days, you can continue with Fillerina
12HA Densifying-Replenishing daily products.


As skin ages, the amount of Hyaluronic Acid gradually
decreases, causing imperfections such as age wrinkles, expression lines and a
loss of plumpness (emptying and skin depressions), especially on cheekbones,
cheeks and lips. Fillerina 12HA Densifying-Replenishing features a patented mix
of 12 different Hyaluronic Acid molecules with varying molecular weights and
sizes that are especially effective in terms of absorption by the skin (ex vivo
tests with Franz Cells), thus allowing it to be replenished and plumped up. The
molecular weights of the 12 Hyaluronic Acids with replenishing effect contained
in this formulation range from 400 to 2000000 Dalton, and up to a Crosspolymer
molecule, and all of them showed a great absorption capability (ex vivo test).


Fillerina 12HA Densifying-Replenishing associates 3 Collagen
molecules with different molecular weights (2 000, 12000 and 300000 Da) which,
thanks to their absorption by the skin (ex vivo test with Franz Cells), can
promote a redensifying effect and improve the replenishing effect, in synergy
with Hyaluronic Acid molecules. With chronological ageing also the quantity and
quality of Elastin, the protein that builds up elastic fibres, drastically
decreases thus threatening skin plasticity and contributing to skin sagging.
The formulation associates 2 molecules of Elastin with different molecular
weights (1400 Da and 2200 Da), which help restore skin elasticity and plasticity.

Labo Skin Technology

The skin is hardly permeable. In order for Fillerina
Hyaluronic Acids and functional molecules to be absorbed by the skin, Labo
researchers developed a patented Technology based on the very low molecular
weight of the active substances. This is the fundamental condition to guarantee
their absorption in the skin. It is precisely thanks to this controlled
absorption that the ingredients are really effective. The percentages reported
here above refer to the skin absorption of the Hyaluronic Acids and of the
functional molecules (Collagens, Elastins), in solution, after 24 hours, which
was made possible by the new Labo technology and tested by means of Franz
Cells. The difference vs the theoretical value 100% represents the sum of experimental
errors in the procedures applied in the study; these differences are considered


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